The hormonal feedback loop that controls the body's own production of testosterone or estrogen. The hypothalamus releases GnRH, the pituitary releases LH and FSH, and the testes or ovaries respond by producing sex hormones.

External anabolic steroids are sensed by the hypothalamus and pituitary as an excess of hormone, and the axis shuts down: LH and FSH fall to near zero and the gonads stop producing. Recovery after stopping happens in sequence, pituitary signal first, then gonadal response, and is confirmed by blood tests for LH, FSH and testosterone rather than by how a person feels.

This article is for information and education only. It is not medical advice and does not replace a consultation with a physician. Anabolic-androgenic steroids are prescription medicines in most countries and are controlled substances in many. Check the law where you live.